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Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons145387

Kretschmer,  Simon
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons15815

Schwille,  Petra
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

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life-04-00915.pdf
(beliebiger Volltext), 536KB

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Zitation

Kretschmer, S., & Schwille, P. (2014). Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies. Life, 4, 915-928. doi:10.3390/life4040915.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0025-798A-4
Zusammenfassung
For reconstruction of controlled cell division in a minimal cell model, or protocell , a positioning mechanism that spatially regulates division is indispensable. In Escherichia coli , the Min protein s oscillate from pole to pole to determine the division site by inhibition of the primary divisome protein FtsZ anywhere but in the cell middle. Remarkably, when reconstituted under defined conditions in vitro , the Min proteins self - organize into spatiotem poral patterns in the presence of a lipid membrane and ATP. We review recent progress made in studying the Min system in vitro , particularly focusing on the effect s of various physicochemical parameters and boundary conditions on pattern formation . Furthermore , we discuss implications and challenges for utilizing the Min system for division site placement in proto cells.