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DNA-protein crosslink repair: proteases as DNA repair enzymes

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons78755

Stingele,  Julian
Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons101406

Habermann,  Bianca
Habermann, Bianca / Computational Biology, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons78165

Jentsch,  Stefan
Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Zitation

Stingele, J., Habermann, B., & Jentsch, S. (2015). DNA-protein crosslink repair: proteases as DNA repair enzymes. Trends in biochemical sciences, 40(2), 67-71. doi:10.1016/j.tibs.2014.10.012.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0025-7765-F
Zusammenfassung
DNA protein crosslinks (DPCs) are highly toxic DNA lesions because they interfere with DNA transactions. The recent discovery of a yeast protease that processes DPCs proteolytically raises the question whether DPC proteases also exist in higher eukaryotes. We argue here that the yeast enzyme, Wss1 (weak suppressor of smt3), is a member of a protease family whose mammalian representative is Spartan (SprT-like domain-containing protein)/DVC1 (DNA damage protein targeting VCP). DPC proteases may thus be common to all eukaryotes where they function as novel guardians of the genome.