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The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle.

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons128786

Spletter,  Maria L.
Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons145330

Barz,  Christiane
Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons141286

Yeroslaviz,  Assa
Habermann, Bianca / Computational Biology, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons78657

Schönbauer,  Cornelia
Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons79377

Ferreira,  Irene R. S.
Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons101406

Habermann,  Bianca H.
Habermann, Bianca / Computational Biology, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons78656

Schnorrer,  Frank
Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

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Zitation

Spletter, M. L., Barz, C., Yeroslaviz, A., Schönbauer, C., Ferreira, I. R. S., Sarov, M., et al. (2015). The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle. EMBO Reports, 16(2), 178-191. doi:10.15252/embr.201439791.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0025-7760-A
Zusammenfassung
In Drosophila, fibrillar flight muscles (IFMs) enable flight, while tubular muscles mediate other body movements. Here, we use RNA-sequencing and isoform-specific reporters to show that spalt major (salm) determines fibrillar muscle physiology by regulating transcription and alternative splicing of a large set of sarcomeric proteins. We identify the RNA-binding protein Arrest (Aret, Bruno) as downstream of salm. Aret shuttles between the cytoplasm and nuclei and is essential for myofibril maturation and sarcomere growth of IFMs. Molecularly, Aret regulates IFM-specific splicing of various salm-dependent sarcomeric targets, including Stretchin and wupA (TnI), and thus maintains muscle fiber integrity. As Aret and its sarcomeric targets are evolutionarily conserved, similar principles may regulate mammalian muscle morphogenesis.