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Concise Total Synthesis of Cruentaren A

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons58380

Fürstner,  A.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons58429

Bindl,  M.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons58643

Jean,  L.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Fürstner, A., Bindl, M., & Jean, L. (2007). Concise Total Synthesis of Cruentaren A. Angewandte Chemie International Edition, 46(48), 9275-9278. doi:10.1002/anie.200703839.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0025-AD36-C
Abstract
Converging on the target: The highly cytotoxic F-ATPase inhibitor cruentaren A constitutes an interesting lead in the quest for innovative chemotherapeutic agents for the treatment of various diseases, including cancer. Its synthesis was achieved in an overall yield of 3 % by an expeditious convergent route involving a ring-closing alkyne metathesis reaction (RCAM) for the formation of the macrocyclic ring.