Concise Total Synthesis of Cruentaren A

Fürstner, A.; Bindl, M.; Jean, L.

doi:10.1002/anie.200703839

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Concise Total Synthesis of Cruentaren A

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Fürstner, A.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Bindl, M.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Jean, L.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Fürstner, A., Bindl, M., & Jean, L. (2007). Concise Total Synthesis of Cruentaren A. Angewandte Chemie International Edition, 46(48), 9275-9278. doi:10.1002/anie.200703839.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0025-AD36-C

Abstract

Converging on the target: The highly cytotoxic F-ATPase inhibitor cruentaren A constitutes an interesting lead in the quest for innovative chemotherapeutic agents for the treatment of various diseases, including cancer. Its synthesis was achieved in an overall yield of 3 % by an expeditious convergent route involving a ring-closing alkyne metathesis reaction (RCAM) for the formation of the macrocyclic ring.