Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl2-Catalyzed 
Cycloisomerization Reaction

Fürstner, Alois; Heilmann, Eike K.; Davies, Paul W.

doi:10.1002/anie.200700895

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Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl₂-Catalyzed Cycloisomerization Reaction

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Fürstner, Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Heilmann, Eike K.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Davies, Paul W.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Fürstner, A., Heilmann, E. K., & Davies, P. W. (2007). Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl₂-Catalyzed Cycloisomerization Reaction. Angewandte Chemie International Edition, 46(25), 4760-4763. doi:10.1002/anie.200700895.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0025-AD05-7

Abstract

Fighting back: A concise route to the pterocarpene derivative erypoegin H, a natural product endowed with considerable activity against a range of methicillin-resistant Staphyllococcus aureus strains and vancomycin-resistant enterococci, has been developed. The key step in the synthesis is a PtCl₂-catalyzed carboalkoxylation reaction of an alkyne (see retrosynthesis; Piv=pivaloyl).