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Journal Article

What is Amphidinolide V? Report on a Likely Conquest

MPS-Authors
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Fürstner,  Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Larionov,  Oleg
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Flügge,  Susanne
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Fürstner, A., Larionov, O., & Flügge, S. (2007). What is Amphidinolide V? Report on a Likely Conquest. Angewandte Chemie International Edition, 46(29), 5545-5548. doi:10.1002/anie.200701640.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0025-ACDD-B
Abstract
The awesome power of metathesis is reflected in the synthesis of the proposed structure of the cytotoxic natural product amphidinolide V, as well as of all other stereomers containing a trans-epoxide unit. It can be concluded from the comprehensive data set obtained that the 8S,9R,10R,13S-configured compound 1 most likely represents amphidinolide V, even though a single resonance in the 1H NMR spectrum deviates from the reported value.