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Zeitschriftenartikel

Molecular motors: structural adaptations to cellular functions

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons93487

Howard,  Joe
Department of Molecular Cell Research, Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Howard, J. (1997). Molecular motors: structural adaptations to cellular functions. Nature, 389(6651), 561-567. doi:10.1038/39247.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0024-B843-9
Zusammenfassung
Molecular motors are protein machines whose directed movement along cytoskeletal filaments is driven by ATP hydrolysis. Eukaryotic cells contain motors that help to transport organelles to their correct cellular locations and to establish and alter cellular morphology during cell locomotion and division. The best-studied motors, myosin from skeletal muscle and conventional kinesin from brain, are remarkably similar in structure, yet have very different functions. These differences can be understood in terms of the 'duty ratio', the fraction of the time that a motor is attached to its filament. Differences in duty ratio can explain the diversity of structures, speeds and oligomerization states of members of the large kinesin, myosin and dynein families of motors