Confirmation of the arginine-finger hypothesis for the GAP-stimulated 
GTP-hydrolysis reaction of Ras

Ahmadian, Mohammad Reza; Stege, Patricia; Scheffzek, Klaus; Wittinghofer, Alfred

doi:10.1038/nsb0997-686

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Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

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Scheffzek, Klaus
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Wittinghofer, Alfred
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Ahmadian, M. R., Stege, P., Scheffzek, K., & Wittinghofer, A. (1997). Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nature structural biology, 4(9), 686-689. doi:10.1038/nsb0997-686.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0024-AF56-6

Abstract

RasGAPs supply a catalytic residue, termed the arginine finger,into the active site of Ras thereby stabilizing the transition state of the GTPase reaction and increasing the reaction rate by more than one thousand-fold, in good agreement with the structure of the Ras.RasGAP complex.