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Flexible adaptive paradigms for fMRI using a novel software package 'Brain Analysis in Real-Time' (BART)

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons19705

Hellrung,  Lydia
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Medicine, University of Leipzig, Germany;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19731

Hollmann,  Maurice
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Zscheyge,  Oliver
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons22945

Schlumm,  Torsten
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19762

Kalberlah,  Christian
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Medicine, University of Leipzig, Germany;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons22937

Roggenhofer,  Elisabeth
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Medicine, University of Leipzig, Germany;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons20065

Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Medicine, University of Leipzig, Germany;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19734

Horstmann,  Annette
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Medicine, University of Leipzig, Germany;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;

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Zitation

Hellrung, L., Hollmann, M., Zscheyge, O., Schlumm, T., Kalberlah, C., Roggenhofer, E., et al. (2015). Flexible adaptive paradigms for fMRI using a novel software package 'Brain Analysis in Real-Time' (BART). PLoS One, 10(4): e0118890. doi:10.1371/journal.pone.0118890.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0024-79FC-8
Zusammenfassung
In this work we present a new software package offering a unified framework for the real-time adaptation of fMRI stimulation procedures. The software provides a straightforward setup and highly flexible approach to adapt fMRI paradigms while the experiment is running. The general framework comprises the inclusion of parameters from subject’s compliance, such as directing gaze to visually presented stimuli and physiological fluctuations, like blood pressure or pulse. Additionally, this approach yields possibilities to investigate complex scientific questions, for example the influence of EEG rhythms or fMRI signals results themselves. To prove the concept of this approach, we used our software in a usability example for an fMRI experiment where the presentation of emotional pictures was dependent on the subject’s gaze position. This can have a significant impact on the results. So far, if this is taken into account during fMRI data analysis, it is commonly done by the post-hoc removal of erroneous trials. Here, we propose an a priori adaptation of the paradigm during the experiment’s runtime. Our fMRI findings clearly show the benefits of an adapted paradigm in terms of statistical power and higher effect sizes in emotion-related brain regions. This can be of special interest for all experiments with low statistical power due to a limited number of subjects, a limited amount of time, costs or available data to analyze, as is the case with real-time fMRI.