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Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons78820

Vahl,  J. Christoph
Schmidt-Supprian, Marc / Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons78080

Heger,  Klaus
Schmidt-Supprian, Marc / Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons138359

Rieß,  David
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons78085

Hein,  Marco Y.
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons78648

Schmidt-Supprian,  Marc
Schmidt-Supprian, Marc / Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Zitation

Vahl, J. C., Drees, C., Heger, K., Heink, S., Fischer, J. C., Nedjic, J., et al. (2014). Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool. IMMUNITY, 41(5), 722-736. doi:10.1016/j.immuni.2014.10.012.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0024-923B-0
Zusammenfassung
Regulatory T (Treg) cells maintain immune homeostasis and prevent inflammatory and autoimmune responses. During development, thymocytes bearing a moderately self-reactive T cell receptor (TCR) can be selected to become Treg cells. Several observations suggest that also in the periphery mature Treg cells continuously receive self-reactive TCR signals. However, the importance of this inherent autoreactivity for Treg cell biology remains poorly defined. To address this open question, we genetically ablated the TCR of mature Treg cells in vivo. These experiments revealed that TCR-induced Treg lineage-defining Foxp3 expression and gene hypomethylation were uncoupled from TCR input in mature Treg cells. However, Treg cell homeostasis, cell-type-specific gene expression and suppressive function critically depend on continuous triggering of their TCR.