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CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons58934

Roiban,  Georghe-Doru
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität Marburg, Fachbereich Chemie;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons58386

Agudo Torres,  Rubén
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität Marburg, Fachbereich Chemie;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons137019

Ilie,  Adriana
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität Marburg, Fachbereich Chemie;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons137066

Londsdale,  Richard
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität Marburg, Fachbereich Chemie;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons58919

Reetz,  Manfred T.
Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Philipps-Universität Marburg, Fachbereich Chemie;

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Citation

Roiban, G.-D., Agudo Torres, R., Ilie, A., Londsdale, R., & Reetz, M. T. (2014). CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity. Chemical Communications, 50(92), 14310-14313. doi:10.1039/C4CC04925J.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0024-5739-1
Abstract
Mutants of P450-BM3 evolved by directed evolution are excellent catalysts in the CH-activating oxidative hydroxylation of 1-tetralone derivatives and of indanone, with unusually high regio- and enantioselectivity being observed. Similar results were achieved in the oxidative hydroxylation of tetralin and indane. The products are useful building blocks in the synthesis of a number of biologically active compounds.