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Journal Article

Neuronal Plasticity: Beyond the Critical Period

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons38901

Hübener,  Mark
Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons38769

Bonhoeffer,  Tobias
Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society;

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Citation

Hübener, M., & Bonhoeffer, T. (2014). Neuronal Plasticity: Beyond the Critical Period. CELL, 159(4), 727-737. doi:10.1016/j.cell.2014.10.035.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0024-59B1-E
Abstract
Neuronal plasticity in the brain is greatly enhanced during critical periods early in life and was long thought to be rather limited thereafter. Studies in primary sensory areas of the neocortex have revealed a substantial degree of plasticity in the mature brain, too. Often, plasticity in the adult neocortex lies dormant but can be reactivated by modifications of sensory input or sensory-motor interactions, which alter the level and pattern of activity in cortical circuits. Such interventions, potentially in combination with drugs targeting molecular brakes on plasticity present in the adult brain, might help recovery of function in the injured or diseased brain.