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Obesity associated cerebral gray and white matter alterations are interrelated in the female brain

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons19872

Mueller,  Karsten
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19734

Horstmann,  Annette
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19864

Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19530

Anwander,  Alfred
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19811

Lepsien,  Jöran
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19981

Schroeter,  Matthias L.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons20065

Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons19926

Pleger,  Burkhard
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Mueller_2014_Obesity.pdf
(Verlagsversion), 2MB

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Zitation

Mueller, K., Horstmann, A., Möller, H. E., Anwander, A., Lepsien, J., Schroeter, M. L., et al. (2014). Obesity associated cerebral gray and white matter alterations are interrelated in the female brain. PLoS One, 9(12): e114206. doi:10.1371/journal.pone.0114206.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0023-CC9D-F
Zusammenfassung
Obesity is known to affect the brain's gray matter (GM) and white matter (WM) structure but the interrelationship of such changes remains unclear. Here we used T1-weighted magnetic resonance imaging (MRI) in combination with voxel-based morphometry (VBM) and diffusion-tensor imaging (DTI) with tract-based spatial statistics (TBSS) to assess the relationship between obesity-associated alterations of gray matter density (GMD) and anisotropic water diffusion in WM, respectively. In a small cohort of lean to obese women, we confirmed previous reports of obesity-associated alterations of GMD in brain regions involved in executive control (i.e., dorsolateral prefrontal cortex, DLPFC) and habit learning (i.e., dorsal striatum). Gray matter density alterations of the DLPFC were negatively correlated with radial diffusivity in the entire corpus callosum. Within the genu of the corpus callosum we found a positive correlation with axial diffusivity. In posterior region and inferior areas of the body of the corpus callosum, axial diffusivity correlated negatively with altered GMD in the dorsal striatum. These findings suggest that, in women, obesity-related alterations of GMD in brain regions involved in executive control and habit learning might relate to alterations of associated WM fiber bundles within the corpus callosum.