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Scaling brain size, keeping timing: evolutionary preservation of brain rhythms

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Buzsáki, G., Logothetis, N., & Singer, W. (2013). Scaling brain size, keeping timing: evolutionary preservation of brain rhythms. Neuron, 80(3), 751-764. doi:10.1016/j.neuron.2013.10.002.


Cite as: http://hdl.handle.net/11858/00-001M-0000-001A-130A-E
Abstract
Despite the several-thousand-fold increase of brain volume during the course of mammalian evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for multiple-time-scale communication within and across neuronal networks at approximately the same speed, irrespective of brain size. Deployment of large-diameter axons of long-range neurons could be a key factor in the preserved time management in growing brains. We discuss the consequences of such preserved network constellation in mental disease, drug discovery, and interventional therapies.