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Sequence and expression of a novel GABAA receptor alpha subunit

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons92704

Draguhn,  Andreas
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons93954

Köhler,  Martin
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons95292

Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Ymer, S., Draguhn, A., Köhler, M., Schofield, P. R., & Seeburg, P. H. (1989). Sequence and expression of a novel GABAA receptor alpha subunit. FEBS Letters, 258(1), 119-122. doi:10.1016/0014-5793(89)81630-8.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0019-AE03-9
Zusammenfassung
Cloned cDNA encoding the bovine alpha 4 subunit of the GABAA receptor has been isolated. The predicted 51 amino acid long mature protein contains an exceptionally long intracellular domain and shares 53-56% sequence similarity to the previously characterized alpha 1, alpha 2 and alpha 3 subunits. Co-expression of alpha 4 and beta 1 in Xenopus oocytes resulted in the formation of GABA-gated chloride channels with expected pharmacology, although no benzodiazepine potentiation was observed. Northern analysis indicates that a 4 kb alpha 4 mRNA is expressed in the calf cerebellum, cortex and hippocampus but is barely detectable in the rat brain