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Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain

MPG-Autoren
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Ruppersberg,  J. Peter
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Schröter,  Klaus
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sakmann,  Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

Externe Ressourcen

http://onlinelibrary.wiley.com/doi/10.1002/j.1460-2075.1989.tb08483.x/epdf
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https://doi.org/10.1002/j.1460-2075.1989.tb08483.x
(beliebiger Volltext)

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Zitation

Stühmer, W., Ruppersberg, J. P., Schröter, K., Sakmann, B., Stocker, M., Giese, K. P., et al. (1989). Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO Journal, 8(11), 3235-3244. doi:10.1002/j.1460-2075.1989.tb08483.x.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0019-ADF5-F
Zusammenfassung
Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.