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Journal Article

Isolation of TSH and LH/CG Receptor cDNAs from Human Thyroid: Regulation by Tissue Specific Splicing

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Sprengel, Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society;
Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Frazier, A. L., Robbins, L. S., Stork, P. J., Sprengel, R., Segaloff, D. L., & Cone, R. D. (1990). Isolation of TSH and LH/CG Receptor cDNAs from Human Thyroid: Regulation by Tissue Specific Splicing. Molecular Endocrinology, 4(8), 1264-1276. doi:10.1210/mend-4-8-1264.

Abstract

A TSH receptor (TSH−R) cDNA has been isolated from a human thyroid {lambda}GT11 library. Unexpectedly, several cDNAs encoding the human LH/CG receptor (LH/CG−R), previously thought to be expressed solely in gonadal cells, were also isolated from the thyroid library. The receptors are structurally related, consisting of a signal sequence, a large extracellular amino terminal domain, seven membrane spanning domains, and a short carboxyl−terminal portion. The TSH−R is encoded by a single 4.2 kilobase mRNA specific to the thyroid. Introns were not present in any hTSH−R cDNAs examined, however, sequencing of several LH/CG−R cDNAs and RNase protection experiments demonstrated that the majority of hLH/ CG−R mRNA in the thyroid is incompletely spliced. Consequently, tissue−specific splicing may be an important step in the regulation of the glycoprotein hormone receptor family