de.mpg.escidoc.pubman.appbase.FacesBean
Deutsch
 
Hilfe Wegweiser Datenschutzhinweis Impressum Kontakt
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONEN
  Dieser Datensatz wurde verworfen!DetailsÜbersicht

Verworfen

Zeitschriftenartikel

Isolation of TSH and LH/CG Receptor cDNAs from Human Thyroid: Regulation by Tissue Specific Splicing

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons95439

Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society;
Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Frazier, A. L., Robbins, L. S., Stork, P. J., Sprengel, R., Segaloff, D. L., & Cone, R. D. (1990). Isolation of TSH and LH/CG Receptor cDNAs from Human Thyroid: Regulation by Tissue Specific Splicing. Molecular Endocrinology, 4(8), 1264-1276. doi:10.1210/mend-4-8-1264.


Zusammenfassung
A TSH receptor (TSH−R) cDNA has been isolated from a human thyroid {lambda}GT11 library. Unexpectedly, several cDNAs encoding the human LH/CG receptor (LH/CG−R), previously thought to be expressed solely in gonadal cells, were also isolated from the thyroid library. The receptors are structurally related, consisting of a signal sequence, a large extracellular amino terminal domain, seven membrane spanning domains, and a short carboxyl−terminal portion. The TSH−R is encoded by a single 4.2 kilobase mRNA specific to the thyroid. Introns were not present in any hTSH−R cDNAs examined, however, sequencing of several LH/CG−R cDNAs and RNase protection experiments demonstrated that the majority of hLH/ CG−R mRNA in the thyroid is incompletely spliced. Consequently, tissue−specific splicing may be an important step in the regulation of the glycoprotein hormone receptor family