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Journal Article

GABAA receptor channels: from subunits to functional entities

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Wisden, W., & Seeburg, P. H. (1992). GABAA receptor channels: from subunits to functional entities. Current Opinion in Neurobiology, 2(3), 263-269. doi:10.1016/0959-4388(92)90113-Y.


Abstract
GABAA receptor channels mediate postsynaptic inhibition. The functional diversity of these receptors rests on differences in subunit composition and on a large repertoire of subunits. Subunit expression patterns in the brain have been found to predict in vivo compositions of GABAA receptors. In addition, molecular determinants underlying the differential binding properties of allosteric ligands to receptor subtypes have been identified