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Vibrational modes of g-actin

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons95655

Tirion,  Monique
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons93463

Holmes,  Kenneth C.
Protein Cristallography XDS, Max Planck Institute for Medical Research, Max Planck Society;
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Muscle Research, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Tirion, M., Ben−Avraham, D., & Holmes, K. C. (1994). Vibrational modes of g-actin. In Advances in Experimental Medicine and Biology (pp. 3-12). New York: Plenum Press.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0019-A9E0-C
Abstract
The determination of the atomic structure of g-actin (Kabsch et al., 1990, see Fig. 1) allowed the development of an atomic model for f-actin (Holmes et al., 1990). The structure of f-actin was deduced from x-ray diffraction patterns from bundles of aligned actin filaments, using the known helical symmetry of the filament and keeping the atomic structure of the monomer fixed. The model of f-actin was obtained, therefore, using only four structural parameters: three rotational and one radial degree of freedom. The solution thus obtained is unique, and achieved an R-factor of.22; an extremely good fit with such few parameters.