de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONS
  This item is discarded!DetailsSummary

Discarded

Journal Article

The hierarchical relationships between the organs of the hypothalamo−hypophyseal−adrenal system (HHAS) in inflammation

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons93189

Grinevich,  Valery
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Valery Grinevich Group, Max Planck Institute for Medical Research, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Grinevich, V., Poskrebysheva, E. A., Savelov, N. A., Abramova, N. A., & Akmayev, I. G. (1999). The hierarchical relationships between the organs of the hypothalamo−hypophyseal−adrenal system (HHAS) in inflammation. Adv. Physiol. Sci., 30(4), 50-66. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10612188.


Abstract
The HPA axis is the major system of adaptation to the action of different stressors, including inflammatory agents. The glucocorticoids, the end product of HPA axis prevent the extension of inflammation. In this article we discuss the classic direct and feedback loops in the HPA axis during acute bacterial inflammation. On the basis of literary and own findings we put forward a speculation that different systemic cytokines released one by one during inflammation induce the appearance of new functional relations between the organs of HPA axis. Because of cytokines are involved in the modulation of hormonal sensitivity in the HPA axis the serious modification of direct as well as feedback relations is postulated. On the other hand cytokines and immune cells induce autocrine and paracrine production of cytokines in the HPA axis, that result in autonomization of pituitary and adrenals functions. So, the acute inflammation factors could be seen as "short−time" functional dominants of HPA axis functioning