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Coherent intramolecular dynamics of enzymic reaction loops in small volumes

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons95456

Stange,  Pedro
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons93404

Hess,  Benno
Emeritus Group Prof. Dr. B. Hess, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Stange, P., Mikhailov, A. S., & Hess, B. (2000). Coherent intramolecular dynamics of enzymic reaction loops in small volumes. Journal of Physical Chemistry B, 104(8), 1844-1853. doi:10.1021/jp992641q.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0019-A1FE-0
Abstract
The diffusive transport and mixing times of regulatory molecules in micrometer and submicrometer reaction volumes can be shorter than characteristic times of conformational transformations in single enzyme molecules. Under these conditions, synchronization of individual molecular turnover cycles takes place when a fraction of the reaction products is converted through a second chemical reaction into the substrate molecules. Using a stochastic model which explicitly describes the internal dynamics of the catalytic process, we analyze the properties of the synchronization transition and the role of statistical fluctuations in the synchronization phenomena