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Colocalization of vasopressin and oxytocin in hypothalamic magnocellular neurons in water−deprived rats

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons93189

Grinevich,  Valery
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Valery Grinevich Group, Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Telleria−Diaz, A., Grinevich, V., & Jirikowski, G. F. (2001). Colocalization of vasopressin and oxytocin in hypothalamic magnocellular neurons in water−deprived rats. Neuropeptides, 35(3), 162-167. doi:10.1054/npep.2001.0859.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0019-A08E-1
Zusammenfassung
The posterior lobe hormones vasopressin and oxytocin are expressed in mutually−exclusive sets of magnocellular hypothamalic neurons. However, under certain functional conditions a partial coexpression has been observed. In the present study we subjected adult rats to long−term osmotic stress by water deprivation for up to 3 days. After 3 days, a marked reduction of vasopressin immunostaining was observed in the paraventricular and supraoptic nuclei as compared with controls. Coexistence of oxytocin and vasopressin occurred in a portion of the magnocellular neurons. Many fibers of the hypothalamic−neurohypophyseal tract contained both peptides. Rehydration for 24 h after 3 days of thirsting resulted in a light recovery of vasopressin immunoreactivity with almost none magnocellular neurons containing both nonapeptides. Our findings indicate that magnocellular hypothalamo neurohypophysial neurons are capable of oxytocin and vasopressin coexpression upon extended osmotic stress