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Journal Article

Inhibitory sharpening of receptive fields contributes to whisker map plasticity in rat somatosensory cortex

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons92449

Celikel,  Tansu
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Foeller, E., Celikel, T., & Feldman, D. E. (2005). Inhibitory sharpening of receptive fields contributes to whisker map plasticity in rat somatosensory cortex. Journal of Neurophysiology, 94(6), 4387-4400. doi:10.1152/jn.00553.2005.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0019-9B58-D
Abstract
The role of inhibition in sensory cortical map plasticity is not well understood. Here we tested whether inhibition contributes to expression of receptive field plasticity in developing rat somatosensory (S1) cortex. In normal rats, microiontophoresis of gabazine (SR 95531), a competitive {gamma}−aminobutyric acid (GABA)−A receptor antagonist, preferentially disinhibited surround whisker responses relative to principal whisker responses, indicating that GABAA inhibition normally acts to sharpen whisker tuning. Plasticity was induced by transiently depriving adolescent rats of all but one whisker; this causes layer 2/3 (L2/3) receptive fields to shift away from the deprived principal whisker and toward the spared surround whisker. In units with shifted receptive fields, gabazine preferentially disinhibited responses to the deprived principal whisker, unlike in controls, suggesting that GABAA inhibition was acting to preferentially suppress these responses relative to spared whisker responses. This effect was not observed for L2/3 units that did not express receptive field plasticity or in layer 4, where receptive field plasticity did not occur. Thus GABAA inhibition promoted expression of sensory map plasticity by helping to sharpen receptive fields around the spared input