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Sister chromatid tension and the spindle assembly checkpoint

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons98714

Musacchio,  Andrea
Abt. I:Mechanistische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Nezi, L., & Musacchio, A. (2009). Sister chromatid tension and the spindle assembly checkpoint. CURRENT OPINION IN CELL BIOLOGY, 21(6), 785-795. doi:10.1016/j.ceb.2009.09.007.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0015-3AE2-4
Abstract
The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response. On the contrary, lack of tension in the centromere-kinetochore region of sister chromatids has been shown to regulate a pathway of correction of undesired chromosome-microtubule connections, while the presence of tension is believed to promote the stabilization of attachments. We discuss how tension-sensitive phenomena, such as attachment correction and stabilization, relate to the SAC and we speculate on the existence of a single pathway linking error correction and SAC activation.