Mineralization of biomimetically carboxymethylated collagen fibrils in a model 
dual membrane diffusion system

Ehrlich, H.; Hanke, T.; Born, R.; Fischer, C.; Frolov, A.; Langrock, T.; Hoffmann, R.; Schwarzenbolz, U.; Henle, T.; Simon, P.; Geiger, D.; Bazhenov, V. V.; Worch, H.

doi:10.1016/j.memsci.2008.10.003

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Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system

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Simon, P.
Paul Simon, Chemical Metal Science, Max Planck Institute for Chemical Physics of Solids, Max Planck Society;

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Citation

Ehrlich, H., Hanke, T., Born, R., Fischer, C., Frolov, A., Langrock, T., et al. (2009). Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system. Journal of Membrane Science, 326, 254-259. doi:10.1016/j.memsci.2008.10.003.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0015-2596-4

Abstract

In the present work, we show for the first time, that N-epsilon-carboxymethyllysine is the major product of the in vitro non-enzymatic glycation reaction between fibrillar collagen and glucuronic acid. Dual diffusion membrane system was effectively used for oriented crystal growth of octacalcium phosphate/hydroxyapatite on the biomimetically carboxymethylated collagen fibrils. We hypothesize that the function of biomimetically carboxymethylated collagen is to increase the local concentration of corresponding ions in such a way that a critical nucleus of ions can be formed, leading to the formation of the mineral under specific micro-environment conditions achieved by using diffusion membrane system. (c) 2008 Elsevier B.V. All rights reserved.