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Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons126855

Simon,  P.
Paul Simon, Chemical Metal Science, Max Planck Institute for Chemical Physics of Solids, Max Planck Society;

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Zitation

Ehrlich, H., Hanke, T., Born, R., Fischer, C., Frolov, A., Langrock, T., et al. (2009). Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system. Journal of Membrane Science, 326, 254-259. doi:10.1016/j.memsci.2008.10.003.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0015-2596-4
Zusammenfassung
In the present work, we show for the first time, that N-epsilon-carboxymethyllysine is the major product of the in vitro non-enzymatic glycation reaction between fibrillar collagen and glucuronic acid. Dual diffusion membrane system was effectively used for oriented crystal growth of octacalcium phosphate/hydroxyapatite on the biomimetically carboxymethylated collagen fibrils. We hypothesize that the function of biomimetically carboxymethylated collagen is to increase the local concentration of corresponding ions in such a way that a critical nucleus of ions can be formed, leading to the formation of the mineral under specific micro-environment conditions achieved by using diffusion membrane system. (c) 2008 Elsevier B.V. All rights reserved.