Imaging the Absolute Configuration of a Chiral Epoxide in the Gas Phase

Herwig, Philipp; Zawatzky , Kerstin; Grieser, Manfred; Heber , Oded; Jordon-Thaden, Brandon; Krantz, Claude; Novotny, Oldrich; Repnow, Roland; Schurig , Volker; Schwalm, Dirk; Vager, Zeev; Wolf, Andreas; Trapp , Oliver; Kreckel, Holger

doi:10.1126/science.1246549

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Imaging the Absolute Configuration of a Chiral Epoxide in the Gas Phase

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Herwig, Philipp
Division Prof. Dr. Klaus Blaum, MPI for Nuclear Physics, Max Planck Society;

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Grieser, Manfred
Division Prof. Dr. Klaus Blaum, MPI for Nuclear Physics, Max Planck Society;

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Jordon-Thaden, Brandon
Division Prof. Dr. Klaus Blaum, MPI for Nuclear Physics, Max Planck Society;

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Krantz, Claude
Division Prof. Dr. Klaus Blaum, MPI for Nuclear Physics, Max Planck Society;

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Novotny, Oldrich
Division Prof. Dr. Klaus Blaum, MPI for Nuclear Physics, Max Planck Society;
Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027, USA. ;

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Repnow, Roland
Division Prof. Dr. Klaus Blaum, MPI for Nuclear Physics, Max Planck Society;

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Schwalm, Dirk
Division Prof. Dr. Klaus Blaum, MPI for Nuclear Physics, Max Planck Society;
Department of Particle Physics and Astrophysics, Weizmann Institute, 76100 Rehovot, Israel. ;

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Wolf, Andreas
Division Prof. Dr. Klaus Blaum, MPI for Nuclear Physics, Max Planck Society;

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Kreckel, Holger
Division Prof. Dr. Klaus Blaum, MPI for Nuclear Physics, Max Planck Society;

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http://www.sciencemag.org/content/342/6162/1084.abstract
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Citation

Herwig, P., Zawatzky, K., Grieser, M., Heber, O., Jordon-Thaden, B., Krantz, C., et al. (2013). Imaging the Absolute Configuration of a Chiral Epoxide in the Gas Phase. Science, 342(6162), 1084-1086. doi: 10.1126/science.1246549.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-BA64-1

Abstract

In chemistry and biology, chirality, or handedness, refers to molecules that exist in two spatial configurations that are incongruent mirror images of one another. Almost all biologically active molecules are chiral, and the correct determination of their absolute configuration is essential for the understanding and the development of processes involving chiral molecules. Anomalous x-ray diffraction and vibrational optical activity measurements are broadly used to determine absolute configurations of solid or liquid samples. Determining absolute configurations of chiral molecules in the gas phase is still a formidable challenge. Here we demonstrate the determination of the absolute configuration of isotopically labeled (R,R)-2,3-dideuterooxirane by foil-induced Coulomb explosion imaging of individual molecules. Our technique provides unambiguous and direct access to the absolute configuration of small gas-phase species, including ions and molecular fragments.