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Comparative Genome-wide DNA Methylation Analysis of Colorectal Tumor and Matched Normal Tissues

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons44040

Assenov,  Yassen
Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons44907

Lengauer,  Thomas
Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons44148

Bock,  Christoph
Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society;

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Volltexte (frei zugänglich)

2012EPI0255R.pdf
(Verlagsversion), 3MB

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Zitation

Simmer, F., Brinkman, A. B., Assenov, Y., Matarese, F., Kaan, A., Sabatino, L., et al. (2012). Comparative Genome-wide DNA Methylation Analysis of Colorectal Tumor and Matched Normal Tissues. Epigenetics, 7(12), 1355-1367. doi:10.4161/epi.22562.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0014-C53B-A
Zusammenfassung
aberrant DNa methylation often occurs in colorectal cancer (cRc). In our study we applied a genome-wide DNa methylation analysis approach, Methylcap-seq, to map the differentially methylated regions (DMRs) in 24 tumors and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potential biomarkers for cRc diagnosis. hypermethylation in the tumor samples was enriched at cpG islands and gene promoters, while hypomethylation was distributed throughout the genome. Using epigenetic data from human embryonic stem cells, we show that frequently hypermethylated regions coincide with bivalent loci in human embryonic stem cells. DNa methylation is commonly thought to lead to gene silencing; however, integration of publically available gene expression data indicates that 75 of the frequently hypermethylated genes were most likely already lowly or not expressed in normal tissue. collectively, our study provides genome-wide DNa methylation maps of cRc, comprehensive lists of DMRs, and gives insights into the role of aberrant DNa methylation in cRc formation.