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Journal Article

The Leiodolide B Puzzle

MPS-Authors
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Larivée,  Alexandre
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Unger,  John B.
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Thomas,  Mickael
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Wirtz,  Cornelia
Service Department Farès (NMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Dubost,  Christophe
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Handa,  Shinya
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Fürstner,  Alois
Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Supplementary Material (public)

anie_201005850_sm_miscellaneous_information.pdf
(Supplementary material), 306KB

Citation

Larivée, A., Unger, J. B., Thomas, M., Wirtz, C., Dubost, C., Handa, S., et al. (2011). The Leiodolide B Puzzle. Angewandte Chemie International Edition, 50(1), 304-309. doi:10.1002/anie.201005850.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-CA27-C
Abstract
Out of options? Even though a systematic approach was chosen, which led to a set of four diastereomeric macrolides modeled around the proposed structure of leiodolide B (see picture), the puzzle concerning the stereostructure of this cytotoxic metabolite derived from a deep-sea sponge still remains unsolved.