de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Direct experimental observation of the aggregation of α-amino acids into 100–200 nm clusters in aqueous solution

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons58696

Klein,  Heinz-Werner
Service Department Schrader (MS), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons58974

Schrader,  Wolfgang
Service Department Schrader (MS), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Hagmeier, D., Ruesing, J., Fenske, T., Klein, H.-W., Schmuck, C., Schrader, W., et al. (2012). Direct experimental observation of the aggregation of α-amino acids into 100–200 nm clusters in aqueous solution. RSC Advances, 2(11), 4690-4696. doi:10.1039/C2RA01352E.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-C9B9-E
Abstract
Spherical supramolecular aggregates of α-amino acids with a typical diameter of 100–200 nm are formed spontaneously after dissolution in water at a concentration of a few mM, i.e. well below the solubility limit. Their presence was shown by nanoparticle tracking analysis (NTA), atomic force microscopy (AFM), and ESI mass spectrometry (ESI-MS). There is a dynamic equilibrium between the aggregates and dissolved individual molecules which allows them to penetrate through dialysis membranes and filters. The same phenomenon was observed for para-amino salicylic acid and two dipeptides. Thermodynamic considerations suggest an entropy-controlled process.