de.mpg.escidoc.pubman.appbase.FacesBean
Deutsch
 
Hilfe Wegweiser Impressum Kontakt Einloggen
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Electron density deformations provide new insights into the spectral shift of rhodopsins

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons101503

Sánchez-García,  Elsa
Research Group Sánchez-García, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)

jcc23414-sup-0001-suppinfo.pdf
(Ergänzendes Material), 4MB

Zitation

Hernández-Rodríguez, E. W., Montero-Alejo, A. L., López, R., Sánchez-García, E., Montero-Cabrera, L. A., & García de la Vega, J. (2013). Electron density deformations provide new insights into the spectral shift of rhodopsins. Journal of Computational Chemistry, 34(28), 2460-2471. doi:10.1002/jcc.23414.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0014-A2C9-4
Zusammenfassung
Spectral shifts of rhodopsin, which are related to variations of the electron distribution in 11-cis-retinal, are investigated here using the method of deformed atoms in molecules. We found that systems carrying the M207R and S186W mutations display large perturbations of the π-conjugated system with respect to wild-type rhodopsins. These changes agree with the predicted behavior of the bond length alternation (BLA) and the blue shifts of vertical excitation energies of these systems. The effect of the planarity of the central and Schiff-base regions of retinal chain on the electronic structure of the chromophore is also investigated. By establishing nonlinear polynomial relations between BLA, chain distortions, and vertical excitation energies, we are also able to provide a semiquantitative approach for the understanding of the mechanisms regulating spectral shifts in rhodopsin and its mutants.