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Journal Article

NEW ENZYMATIC PROTECTING GROUP TECHNIQUES FOR PEPTIDE AND CARBOHYDRATE CHEMISTRY

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons98735

Waldmann,  Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Waldmann, H., HEUSER, A., BRAUN, P., & KUNZ, H. (1992). NEW ENZYMATIC PROTECTING GROUP TECHNIQUES FOR PEPTIDE AND CARBOHYDRATE CHEMISTRY. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 31(12), 799-802.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-9B64-C
Abstract
New methods are reported to establish enzymatic techniques for the chemo- and regioselective functionalization of carbohydrates, peptides and glycoconjugates. The N-terminal deprotection of peptides is achieved via hydrolysis of phenylacetamides, employing penicillin G acylase as biocatalyst. The C-terminal carboxyl function of peptides and O-glycopeptides is liberated by the lipase-mediated hydrolysis of heptyl esters. Penicillin G acylase and citrus acetylesterase are used to effect the chemo- and regioselective removal of phenylacetyl and acetyl blocking groups, respectively from differently protected carbohydrates.