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SELECTIVE ENZYMATIC REMOVAL OF PROTECTING FUNCTIONS - HEPTYL ESTERS AS CARBOXY PROTECTING GROUPS IN GLYCOPEPTIDE SYNTHESIS

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons98735

Waldmann,  Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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BRAUN, P., Waldmann, H., & KUNZ, H. (1992). SELECTIVE ENZYMATIC REMOVAL OF PROTECTING FUNCTIONS - HEPTYL ESTERS AS CARBOXY PROTECTING GROUPS IN GLYCOPEPTIDE SYNTHESIS. SYNLETT, (1), 39-40.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-9B5D-D
Abstract
The selective C-terminal deprotection of acid- and base-labile multifunctional O-glycopeptide heptyl (Hep) esters is achieved under mild conditions (pH 7; 37-degrees-C) by enzymatic hydrolysis with a lipase from Mucor javanicus.