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Journal Article

ENHANCEMENT OF THE ENANTIOSELECTIVITY OF PENICILLIN-G ACYLASE FROM ESCHERICHIA-COLI BY SUBSTRATE TUNING

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons98735

Waldmann,  Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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POHL, T., & Waldmann, H. (1995). ENHANCEMENT OF THE ENANTIOSELECTIVITY OF PENICILLIN-G ACYLASE FROM ESCHERICHIA-COLI BY SUBSTRATE TUNING. TETRAHEDRON LETTERS, 36(17), 2963-2966. doi:10.1016/0040-4039(95)00440-N.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-729A-9
Abstract
The efficiency of penicillin G acylase catalyzed transformations is enhanced significantly with respect to reaction velocity, and in particular, stereoselectivity by appropriate ''substrate tuning'', i.e. by the introduction of a nitrogen atom into the part of the substrates which is recognized by the enzyme.