Chemoenzymatic synthesis of a characteristic phosphopeptide fragment of the 
Raf-1 kinase

Sebastian, D; Waldmann, Herbert

doi:10.1016/S0040-4039(97)00514-5

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Chemoenzymatic synthesis of a characteristic phosphopeptide fragment of the Raf-1 kinase

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Waldmann, Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Sebastian, D., & Waldmann, H. (1997). Chemoenzymatic synthesis of a characteristic phosphopeptide fragment of the Raf-1 kinase. TETRAHEDRON LETTERS, 38(17), 2927-2930. doi:10.1016/S0040-4039(97)00514-5.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-71E1-F

Abstract

Base-labile biologically relevant phosphopeptides can advantageously be synthesized under very mild conditions (pH 7, 37 degrees C) by employing the heptyl (Hep) ester as enzyme-labile protecting group. This method was used in the construction of a characteristic, selectively phosphorylated hydroxyamino acid fragment of the Raf-l kinase, an important constituent of the Ras pathway of signal transduction. (C) 1997 Elsevier Science Ltd.