de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Enzymatic synthesis of peptide conjugates: Tools for the study of biological signal transduction

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons98735

Waldmann,  Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Kappes, T., & Waldmann, H. (1997). Enzymatic synthesis of peptide conjugates: Tools for the study of biological signal transduction. Liebigs Annalen, 1997(5), 803-813. doi:10.1002/jlac.199719970504.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-71DF-8
Abstract
Glyco-, phospho-, nucleo- and lipoproteins play key roles in biological signalling cascades, by which chemical signals are passed across the cell membrane and further to the cell nucleus. For the study of the biological phenomena associated with these protein conjugates, structurally well-defined peptides containing the characteristic linkage region of the peptide backbone with the carbohydrate, the Lipid or the phosphoric acid ester can be applied advantageously. The multifunctionality and the pronounced acid- and base-lability of lipo-, phospho-, nucleo- and glycopeptides, however, renders their synthesis a formidable challenge to conventional or ganic synthesis. This review highlights the potential of enzymatic transformations, in particular for the removal of protecting groups, as central techniques for the construction of complex and sensitive biologically relevant peptide conjugates under particularly mild conditions and with high selectivity.