Efficient enantioselective synthesis of a beta-hydroxyepoxide building block 
for the construction of macrocyclic natural products

Schlede, U; Nazare, M; Waldmann, Herbert

doi:10.1016/S0040-4039(97)10874-7

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Efficient enantioselective synthesis of a beta-hydroxyepoxide building block for the construction of macrocyclic natural products

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Waldmann, Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Schlede, U., Nazare, M., & Waldmann, H. (1998). Efficient enantioselective synthesis of a beta-hydroxyepoxide building block for the construction of macrocyclic natural products. TETRAHEDRON LETTERS, 39(10), 1143-1144. doi:10.1016/S0040-4039(97)10874-7.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-71B8-D

Abstract

The synthesis of a protected beta-hydroxyepoxide macrolide building block in seven steps from commercially available (R)-3-hydroxybutyric acid methyl ester in 68% overall yield is described. (C) 1998 Elsevier Science Ltd. All rights reserved.