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Journal Article

Optogenetic Control of Fly Optomotor Responses

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons101829

Haikala,  Väinö
Department: Circuits-Computation-Models / Borst, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons38912

Joesch,  Maximilian
Department: Circuits-Computation-Models / Borst, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons38770

Borst,  Alexander
Department: Circuits-Computation-Models / Borst, MPI of Neurobiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons38988

Mauss,  Alex S.
Department: Circuits-Computation-Models / Borst, MPI of Neurobiology, Max Planck Society;

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Citation

Haikala, V., Joesch, M., Borst, A., & Mauss, A. S. (2013). Optogenetic Control of Fly Optomotor Responses. JOURNAL OF NEUROSCIENCE, 33(34), 13927-13934. doi:10.1523/JNEUROSCI.0340-13.2013.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-52E3-D
Abstract
When confronted with a large-field stimulus rotating around the vertical body axis, flies display a following behavior called "optomotor response." As neural control elements, the large tangential horizontal system (HS) cells of the lobula plate have been prime candidates for long. Here, we applied optogenetic stimulation of HS cells to evaluate their behavioral role in Drosophila. To minimize interference of the optical activation of channelrhodopsin-2 with the visual perception of the flies, we used a bistable variant called ChR2-C128S. By applying pulses of blue and yellow light, we first demonstrate electrophysiologically that lobula plate tangential cells can be activated and deactivated repeatedly with no evident change in depolarization strength over trials. We next show that selective optogenetic activation of HS cells elicits robust yaw head movements and yaw turning responses in fixed and tethered flying flies, respectively.