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Abstract

The exploitation of new catalysts and new organic transformations in an environmentally benign manner has became crucially important in recent years for the construction of new and useful organic structures from versatile starting materials. In this context, organocatalysis has recently emerged as a powerful synthetic paradigm in order to fill a gap between metal- and enzyme-catalysis, thereby providing practical alternatives or complementary technologies to the more traditional transition metal-catalyzed systems. Organocatalysis is an attractive method to synthesize complex organic molecules: it is operationally simple, has low associated toxicity and organocatalysts are simple to handle and store. In addition, a wide variety of organocatalysts are now commercially available, which will further stimulate the wide application of such organocatalysts for selective organic transformations in a broad manner. Indeed, organocatalysis has seen a tremendous rise in popularity when measured in recent scientific publications. A tremendous amount of new experimental findings have been published at a breathtaking pace over the last several years which implies the “golden age” and “gold rush” of the organocatalytic field.

The communications and feature articles in this web collection cover important up-to-date information on organocatalysis, and sketch the fruitful development of this exciting field. In particular, the major contributions originated from (1) enamine and iminium catalysis; (2) SOMO and radical enamine catalysis; (3) amine, DMAP and phosphine catalysis; (4) carbene-catalysis, ketone and iminium salt catalysis; (5) organocatalysis using guanidine, amidine and Cinchona alkaloids; (6) organocatalysis with Brønsted acids, thiourea and peptides; and (7) phase-transfer catalysis. In addition, several one-pot multi-step procedures lead to highly functionalized products of wide synthetic applicability. The articles in this issue demonstrate a high, yet sophisticated level of activity in addition to the scope and limitations of this promising field. Accordingly, the readers will enjoy reading the most recent and exciting findings in the current organocatalytic field.