Catalytic asymmetric hydrogenation of aldehydes

Li, Xiaoguang; List, Benjamin

doi:10.1039/b703977h

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Catalytic asymmetric hydrogenation of aldehydes

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Li, Xiaoguang
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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List, Benjamin
Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Li, X., & List, B. (2007). Catalytic asymmetric hydrogenation of aldehydes. Chemical Communications, 2007(17), 1739-1741. doi:10.1039/b703977h.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-A454-B

Abstract

Racemic α-arylaldehydes provide the corresponding primary alcoholsvia dynamic kinetic resolution in excellent enantioselectivities and yields upon hydrogenation using a Noyori ruthenium catalyst; for example, the biologically active (S)-enantiomer of the non-steroidal anti-inflammatory drug ibuprofen could be synthesized via catalytic enantioselective hydrogenation of aldehyde1f followed by oxidation with potassium permanganate in 76% isolated yield and 96 : 4 er.