de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Conference Paper

Statistical methods for comparing comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry results: Metabolomic analysis of mouse tissue extracts

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons97148

Fiehn,  O.
Metabolomic Analysis, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Shellie, R. A., Welthagen, W., Zrostlikova, J., Spranger, J., Ristow, M., Fiehn, O., et al. (2005). Statistical methods for comparing comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry results: Metabolomic analysis of mouse tissue extracts. In 2nd International Symposium on Comprehensive Multidimensional Gas Chromatography (pp. 83-90).


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-2B1A-C
Abstract
The potential for the utilization of GC x GC-time-of-flight (TOF) MS for high-resolution metabolomics studies is discussed, with the implementation of some statistical comparisons for biomarker detection. Metabolite profiles from NZO obese mice versus BL/6 control mice are compared and contrasted using a number of chromatogram comparison routines, including direct chromatogram comparisons, chromatogram subtraction and averaging routines, as well as a method for generating relative weighted peak surface difference chromatograms, and a more conventional Student's t-test statistical approach. (c) 2005 Elsevier B.V. All rights reserved.