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Enzymatically cleavable linker groups in polymer-supported synthesis

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Reents,  Reinhard
Max Planck Institute of Molecular Physiology, Max Planck Society;

Jeyaraj,  Duraiswamy A.
Max Planck Institute of Molecular Physiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons98735

Waldmann,  Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Reents, R., Jeyaraj, D. A., & Waldmann, H. (2002). Enzymatically cleavable linker groups in polymer-supported synthesis. Drug Discovery Today, 7(1): 1, pp. 71-76. Retrieved from http://dx.doi.org/10.1016/S1359-6446(01)02088-8.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-0F11-D
Abstract
Access to broadly applicable linker groups that are stable under a variety of reaction conditions and enable the release of target compounds from polymeric supports under the mildest conditions is a major goal in combinatorial chemistry. Here, we summarize the development of enzymatically cleavable linker groups used to prepare a variety of different target molecules on polymeric supports.