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New indene-derivatives with anti-proliferative properties

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Karaguni,  Ioanna-Maria
Max Planck Institute of Molecular Physiology, Max Planck Society;

Langerak,  Anette
Max Planck Institute of Molecular Physiology, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons98712

Müller,  Oliver
Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Karaguni, I.-M., Glusenkamp, K.-H., Langerak, A., Geisen, C., Ullrich, V., Winde, G., et al. (2002). New indene-derivatives with anti-proliferative properties. Bioorganic & Medicinal Chemistry Letters, 12(4): 1, pp. 709-713. Retrieved from http://dx.doi.org/10.1016/S0960-894X(01)00839-3.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-0EE1-0
Abstract
Metabolites of the non-steroidal anti-inflammatory drug Sulindac inhibit cell proliferation by affecting several intracellular signaling pathways including the tumorigenic Ras/Raf/MAPK pathway. Here, we report the synthesis of eight new indene derivatives derived from the Sulindac structure, and present data on their anti-proliferative properties and their effects on the p21ras protein. (C) 2002 Elsevier Science Ltd. All rights reserved.