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Patent: Technique and Screening Method for Detecting Reversible Protein-Protein Interactions

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons98738

Wittinghofer,  Alfred
Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society;

Rocks,  Oliver
Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Wittinghofer, A., & Rocks, O. (2002). Patent: Technique and Screening Method for Detecting Reversible Protein-Protein Interactions. Weltorganisation für geistiges Eigentum.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0014-0E41-9
Abstract
The invention relates to methods and assays for detecting protein-protein interactions and for testing active substances in expression systems such as cells. According to the invention, protein I interacts with protein II, and a transfer of protein I into a cell compartment ensues, in which both protein I as well as protein II do not normally occur. When detecting protein II in the compartment, into which protein I was transferred, an interaction between protein I and protein II is determined.