Ras-effector interactions: after one decade

Herrmann, Christian

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Ras-effector interactions: after one decade

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Herrmann, Christian
Max Planck Institute of Molecular Physiology, Max Planck Society;

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Herrmann, C. (2003). Ras-effector interactions: after one decade. Current Opinion in Structural Biology, 13(1): 1, pp. 122-129. Retrieved from http://dx.doi.org/10.1016/S0959-440X(02)00007-6.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-0CB6-4

Abstract

Ras effectors have convergently developed a common subdomain in their otherwise unrelated protein body for their interaction with Ras. Structural analysis revealed that the mode of interaction is highly similar for all Ras effectors, but is completely different from that of effectors of other subfamilies of small GTPases. Whereas the molecular mechanism of effector activation is still elusive, detailed knowledge about the thermodynamics and dynamics of the interaction with Ras has accumulated.