GABA-antagonist inverts movement and object detection in flies

Bülthoff, HH; Bülthoff, I

doi:10.1016/0006-8993(87)91230-3

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GABA-antagonist inverts movement and object detection in flies

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Bülthoff, HH
Former Department Neurophysiology of Insect Behavior, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Bülthoff, I
Former Department Neurophysiology of Insect Behavior, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/0006899387912303
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Citation

Bülthoff, H., & Bülthoff, I. (1987). GABA-antagonist inverts movement and object detection in flies. Brain Research, 407(1), 152-158. doi:10.1016/0006-8993(87)91230-3.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-EFA5-C

Abstract

Movement detection is one of the most elementary visual computations performed by vertebrates as well as invertebrates. However, comparatively little is known about the biophysical mechanisms underlying this computation. It has been proposed on both physiological1.8.21 and theoretical2.15.23 grounds that inhibition plays a crucial role in the directional selectivity of elementary movement detectors (EMDs). For the first time, we have studied electrophysiological and behavioral changes induced in flies after application of picrotoxinin, an antagonist of GABA. The results show that inhibitory interactions play an important role in movement detection in flies. Furthermore, our behavioral results suggest that the computation of object position is based primarily on movement detection.