de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human gastric lumen

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84187

Bilecen D, Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Kaspar, A., Bilecen D, Scheffler, K., & Seelig, J. (1996). Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human gastric lumen. Magnetic Resonance in Medicine, 36(2), 177-182. doi:10.1002/mrm.1910360202.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-EB40-E
Abstract
Aluminum NMR is proposed as a new imaging and spectroscopy modality. Its potential is exemplified by in vivo studies of the human stomach. The dissolution kinetics of aluminum-containing drugs at physiological doses and their removal from the human stomach have been followed by 27Al magnetic resonance spectroscopy (MRS). Aluminum concentrations as low as 0.5 mg Al3+ in the human stomach can be detected. The time course of gastric emptying has been visualized with 27Al magnetic resonance imaging (MRI) under normal conditions and in the presence of an antimuscarinic agent, which reduces the gastric motor function. 27Al MRI is the only direct method to visualize the gastric pH. 27Al MRI opens new possibilities for medical and pharmaceutical science.