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Effects of volatile anaesthetics on spontaneous action potential firing of cerebellar Purkinje cells in vitro do not follow the Meyer-Overton rule.

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons83785

Antkowiak,  B
Former Department Comparative Neurobiology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83964

Hentschke,  H
Former Department Comparative Neurobiology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84015

Kirschfeld,  K
Former Department Comparative Neurobiology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Antkowiak, B., Hentschke, H., & Kirschfeld, K. (1997). Effects of volatile anaesthetics on spontaneous action potential firing of cerebellar Purkinje cells in vitro do not follow the Meyer-Overton rule. British Journal of Anaesthesia, 79, 617-624.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-EA8E-6
Abstract
We have investigated in rat brain slices the effects of the volatile anaesthetics enflurane, isoflurane and halothane on spontaneous discharge patterns and mean firing rates of cerebellar Purkinje cells. In the absence of these anaesthetics, Purkinje cells fired bursts of action potentials separated by quiescent periods lasting less than 2 s. Mean discharge rates were 10.8 (SEM 0.4) Hz at 23+/-1 degrees C and 25.6 (1.2) Hz at 35+/-1 degrees C. The agents exhibited qualitatively different effects when applied at concentrations corresponding to 1-3 MAC. Enflurane markedly lengthened burst and inter-burst durations. Isoflurane acted in a similar manner, but effects were less pronounced. In contrast with isoflurane and enflurane, halothane shortened burst durations. At concentrations corresponding to 1-1.5 MAC, halothane, isoflurane and enflurane significantly depressed action potential firing by 15-30 (P