de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Metamorphosis of the mushroom bodies; large scale rearrangements of the neural substrates for associative learning and memory in Drosophila.

MPS-Authors
There are no MPG-Authors available
Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

JD, A., de JS, B., Z, W., & K, K. (1998). Metamorphosis of the mushroom bodies; large scale rearrangements of the neural substrates for associative learning and memory in Drosophila. Learning Memory, 5, 102-114.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-E921-2
Abstract
Paired brain centers known as mushroom bodies are key features of the circuitry for insect associative learning, especially when evoked by olfactory cues. Mushroom bodies have an embryonic origin, and unlike most other brain structures they exhibit developmental continuity, being prominent components of both the larval and the adult CNS, Here, we use cell-type- specific markers, provided by the PGAL4 enhancer trap system, to follow specific subsets of mushroom body intrinsic and extrinsic neurons from the larval to the adult stage. We find marked structural differences between the larval and adult mushroom bodies, arising as the consequence of large-scale reorganization during metamorphosis. Extensive, though incomplete, degradation of the larval structure is followed by establishment of adult specific alpha and beta lobes, Kenyon cells of embryonic origin, by contrast, were found to project selectively to the adult gamma lobe, We propose that the gamma lobe stores information of relevance to both developmental stages, whereas the alpha and beta lobes have uniquely adult roles.