Cholinergic modulation of spike timing and spike rate

Tang, AC; Wolfe, J; Bartels, A

doi:10.1016/S0925-2312(99)00072-7

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Cholinergic modulation of spike timing and spike rate

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

https://www.sciencedirect.com/science/article/pii/S0925231299000727
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Tang, A., Wolfe, J., & Bartels, A. (1999). Cholinergic modulation of spike timing and spike rate. Neurocomputing, 26-27, 293-298. doi:10.1016/S0925-2312(99)00072-7.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-E68F-6

Abstract

Little is known about the constraints that neuromodulation places upon neural coding. We investigated the relationship between cholinergic modulation of spike timing and rate in a compartment model of a neocortical neuron. Our results suggest that cholinergic modulation of spike timing is directly related to the modulation of spike rate via the insertion of new spikes, and that spike timing is best preserved when the firing rate is low, i.e., when a rate code is ineffective (Thorpe et al., Nature 381 (6582) (1996) 520-522). We propose that neocortical neurons may use a spike timing and a rate code complementarily in different portions of their dynamic range.