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Can current fMRI techniques reveal the micro-architecture of cortex?

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis, N. (2000). Can current fMRI techniques reveal the micro-architecture of cortex? Nature Neuroscience, 3(5), 413-413. doi:10.1038/74768.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-E4DD-4
Abstract
In a recent paper in Nature Neuroscience, Kim et al.1 claimed to have visualized orientation columns in the visual cortex of cats by means of high-field, spatially resolved functional magnetic resonance imaging (fMRI). This would represent a striking technical advance indeed, if their mapping method were robust to noise and if the recorded patterns were reproducible within a given experimental session. A careful examination of their data, however, suggests that this may not be the case. Because the maps obtained in this study rely on a specific phase of the hemodynamic response, I will begin by briefly reviewing a few basic principles.